I started with 50 Lockpicking...
To start raising this skill you will need some lockable boxes made by someone who has 50 tinker skill. You may try to find them on vendor, but it is easier to create a new char with 50 carpentry and 50 tinkering.
I made 4 lockable boxes for my treasure hunter, bought some lockpicks and started writing my macro...
Macro to raise lockpicking:
Double Click on the key from the first box
Wait for Target
Absolute Target (the first box)
Pause 1.00sec
Double Click on the key from the second box
Wait for Target
Absolute Target (the second box)
Pause 1.00sec
Double Click on the key from the third box
Wait for Target
Absolute Target (the third box)
Pause 1.00sec
Double Click on the key from the fourth box
Wait for Target
Absolute Target (the fourth box)
Pause 1.00sec
Double Click (lockpicks)
Wait for Target
Absolute Target (our first box)
Pause 4.00sec
Double Click (lockpicks)
Wait for Target
Absolute Target (second box)
Pause 4.00sec
Double Click (lockpicks)
Wait for Target
Absolute Target (third box)
Pause 4.00sec
Double Click (lockpicks)
Wait for Target
Absolute Target (fourth box)
Pause 4.00sec
-------------------------------------------------------------
That's it. after this, i let my char at home macroing...
i dont really remember how much time it took to reach 74.4 (real), but the problem is that the skill stopped raising.
To continue raising you need to get some GM locked boxes. In my case, i found a vendor, near the Vesper Bank, that was selling them. With them and this macro you will reach 95.0 of the skill. After this you will need to start digging treasures and/or open treasure chests in dungeons to raise lockpicking...
P.S.: for those who is looking for 75 tinker made locked boxes on trading forum, dont bother, just get 50 and GM made and start working

P.P.S.: sorry for my english...